Last Updated on November 23, 2019 by Marc Seward

Medically Reviewed by Dr. BENGEBARA Omar
MD, ER Doctor & Surgery Resident – Reviewed & Approved on November 05, 2018
–Written by Marc Seward

Peripheral neuropathy refers to a condition where nerves are damaged and are characterized by numbness, pain, and tingling of the nerves.

Neuropathy is caused by a wide variety of factors including illnesses such as diabetes, chemotherapy treatments, certain medications, vitamin deficiency, injury, and infection.

Around half of people suffering from neuropathy are actually diabetic. The damaged nerves can cause misfiring messages which transfer pain signals to the brain despite there being no physical reason for pain.

Neuropathy has proven a very difficult condition for the medical profession to tackle and with that in mind, many sufferers are looking towards alternative remedies to improve or at least control their symptoms.

We have already covered home remedies for neuropathy here as well as taking a look at the effects of essential oils on neuropathy which you can read about in some detail here.

Certain vitamins and supplements may be able to play a significant role in the treatment of diabetic and peripheral neuropathy and this article will examine the evidence to date.

What is Neuropathy?

Fast Facts

Neuropathy is a relatively common complication associated with a number of different medical conditions but can also be caused by trauma and several other factors.
Neuropathy may affect the motor nerves, the sensory nerves or the autonomic nerves, the symptoms vary depending on which nerves are affected.
Sometimes neuropathy only affects one nerve or a single nerve set. One example is Bell’s Palsy which only affects the facial nerve.
Neuropathy is linked strongly to diabetes. Over half of all diabetics will suffer from some kind of neuropathy.
Infection, repetitive strain and physical injury are all potential causes of neuropathy.
Diet is important. Neuropathy has been linked with a deficiency in vitamin B-12 and other members of the B vitamin family.

Neuropathy is a common and painful condition which occurs after damage to the peripheral nerves. The peripheral nervous system runs through the entire body connecting the nerves in the central nervous system with the rest of your body which includes the limbs, face, mouth, skin, muscles and organs. The peripheral nerves are responsible for relaying messages about any physical sensation you experience to the brain.

When these nerves are damaged or destroyed, they fail to perform their job effectively which results in the condition we know as neuropathy. As a result, people with the condition may not feel pain when they should or experience feelings of pain when there is no physical reason for it.

Symptoms of Neuropathy

The symptoms of neuropathy will vary depending on which nerves are affected. The following are some of the most common symptoms..

Sensory Neuropathy

numbness and tingling which often begins in the toes and fingers but can spread into the limbs.
hypersensitivity to touch
pins and needles
feeling pain when there is no physical reason or feeling no pain when you should
an inability to feel changes in temperature
stabbing or shooting pains which often feel worse at night

Motor Neuropathy

This type of neuropathy affects the muscles and causes the following symptoms:

muscle weakness
difficulties with coordination
falling and stumbling
muscle wasting
muscle twitching
cramps
paralysis.

If a person’s autonomic nerves are damaged, they may experience palpitations, heat intolerance, sweating problems, blood pressure issues and dizziness as well as problems with digestion and the bladder.

Vitamins and Supplements for Neuropathy

Alpha Lipoic Acid

An essential fatty acid known as Alpha lipoic acid (ALA) is a compound produced in the body which is present in all of our cells.

ALA plays a vital role in the performance of many of our body’s functions especially with regard to the metabolism of glucose; it is both a powerful antioxidant and helps produce energy from blood sugar.

B-Vitamins

The B vitamins are a group of vitamins that play many vital roles in the body including nerve function and generating cellular energy.

Thiamine and Benfotiamine

According to research, a thiamine deficiency can directly lead to neuropathy and there is some evidence that thiamine supplements can help treat the condition, especially diabetic neuropathy.

Benfotiamine is a derivative of thiamine which is fat-soluble and more easily absorbed into the digestive system.

According to the research so far, benfotiamine modulates the pathways that cause neuropathy.

It regulates cellular damage caused by high levels of glucose and prevents vascular problems that also contribute to neuropathy.

Several trials have demonstrated that benfotiamine taken at doses between 300 and 600 mg a day can significantly relieve the symptoms of diabetic neuropathy. (4) (5)

Vitamin B12 and Vitamin B6

Vitamin B12 is absolutely crucial to a well-functioning nerve system and a deficiency can lead directly to peripheral neuropathy.

Several studies on animals and humans have offered promising results so far.

Several studies on animals have demonstrated that Vitamin B12 can extenuate nerve damage caused by neuropathy by activating a chemical signal, which helps nerves to regenerate. (6)

Clinical trials have also demonstrated how significant ViaminsB12 and B6 are in the treatment of neuropathic symptoms.

Combinations of Vitamin B12 and B6 (methylcobalamin, folic acid, and pyridoxal) have been found to improve symptoms and maintain the health of nerves in the extremities. (7)

Another study found that a combination of the same B-Vitamins reduced periods of hospitalization and medical costs in those with diabetic neuropathy.

Research into the effects of methylcobalamin (a type of Vitamin B-12) has been promising too. Taken orally at 1500 mcg a day, research has found that it improves symptoms including numbness, pain, and gait and it also proved more effective than nortriptyline, a commonly prescribed antidepressant to treat neuropathic pain. (8)

Vitamin C

This vitamin is especially significant to diabetic neuropathy because research shows that most diabetics have a lack of Vitamin C as a result of their illness rather than diet.

Those suffering from diabetic neuropathy have an elevated level of vitamin c which the body has already used known as reduced Vitamin C. This implies that neuropathy places an extra strain on the body’s Vitamin C stores. As a result, it is important for diabetics to get sufficient levels of this vitamin through supplementation or diet.

Vitamin E

Lower levels of Vitamin E can also be seen in people suffering from diabetic neuropathy.

Research has shown that supplementing with Vitamin E alone can improve peripheral neuropathy symptoms and improve nerve function and health in those with type 2 diabetes. (9)

Vitamin D

A deficiency in Vitamin D may be a risk factor in peripheral diabetic neuropathy. A deficiency is typically present in those with type 1 and 2 diabetes and is even more common in those suffering neuropathy symptoms.

One study published in 2008 was carried out on 51 patients and found that supplementing with Vitamin D reduced pain levels by up to 50%. (10)

Acetyl l-Carnitine

This is an amino acid which is often used to treat a range of illnesses including Alzheimer’s disease, diabetic neuropathy and other forms of neuropathy.

Because carnitine is often lacking in those with diabetic neuropathy, there has been some research to evaluate the role of supplementation.

According to research, supplementing with carnitine might help increase insulin resistance, allow the cells to utilize glucose effectively and boost nerve regeneration. (11)

Several studies into the effects of Acetyl l-carnitine have discovered that it helps reduce pain, improves the sensation of vibration in the limbs and helps nerves to regenerate. (11) (12)

Note: People taking blood thinning medications like warfarin should not use Acetyl l-carnitine. the combination increases the effects of warfarin and can increase the risks of bleeding.

N-acetyl cysteine (NAC)

Supplementing with NAC might help treat the symptoms of neuropathy; it functions as a potent antioxidant as well as increasing the potential of naturally occurring antioxidants in the body like glutathione.

According to research, NAC protects the nerves from oxidative stress and damage.
(13)

Curcumin

Curcumin is a yellow colored pigment extracted from a plant called Curcuma longa. There is a great deal of hope that curcumin, which is the main active compound in turmeric, could be used as a supplement for those suffering from neuropathy.

It is an excellent anti-inflammatory and according to research might be able to reduce pain signals caused by damaged nerves as well as prevent oxidative damage of the nerves. (14)

Curcumin is available in supplementary form and can also be found in high levels in turmeric.

Resveratrol supplements

Resveratrol is a phytochemical available in a supplementary form and also present in grapes and red wine. Animal studies have shown that it protects against neuropathy because of its ability to fight inflammation and oxidative stress. One study demonstrated that resveratrol combined with insulin reduced sensitivity to pains. (15)

Magnesium

Research suggests that the majority of us in the West are deficient in magnesium. It performs many vital functions including clotting the blood and allowing proper muscle and nerve function..

According to research, diabetic neuropathy symptoms are exacerbated by magnesium deficiencies and it is recommended that supplements are used because we do not get enough from our diets.

The recommended dose of magnesium is 400 mg taken twice daily.

Fish Oil

Rich in oega-3 fatty acids, fish oil can be extremely useful for treating neuropathy. It is effective because of its anti-inflammatory abilities as well as its proven abilities to repair and heal damaged nerves. Fish oil can also help relieve muscle pain and soreness.

Fish oil is readily available in supplementary form and is regarded as effective and safe in daily doses between 2,400 and 5400 mg.

As well as getting fish oil from supplements, a variety of foods are also high in omega-3 fatty acids. These include :

mackerel, salmon, herring, anchovies and sardines
oysters
walnuts
chia seeds and flaxseeds
cod liver oil
canola oil
soybeans

A review, published in 2017, looked at the effects of fish oil as a natural treatment for neuropathy – specifically diabetic peripheral neuropathy. According to the review, fish oil holds promise and a number of studies have revealed that fish oil has the ability to slow down the progression or even to reverse the condition. (16)

The research suggests that fish oil is useful because of its neuroprotective effects that can stimulate the regrowth of neurons. The natural anti-inflammatory effects of fish oil can also reduce pain and ease discomfort.

Lifestyle Changes for Neuropathy

For people suffering with neuropathy, certain lifestyle changes can have a very positive effect. Eating well is very important while getting plenty of exercise can also make a difference.

Eat a Healthy Diet : While research into the link between neuropathy and dietary supplements is ongoing, most experts agree that eating a good healthy diet is critical. This is especially true of people suffering from diabetic neuropathy. Diabetics should try to eat a diet rich in essential nutrients while low in calories and fat. Try to eat plenty of fresh fruit and vegetables as well as whole grains and legumes. Neuropathy has also been linked to a deficiency in vitamin B-12. Foods rich in B-12 include poultry, lean meaty, fish and eggs.
Get Plenty of Exercise : Exercise can play an important role in managing blood sugar levels in people with diabetic neuropathy but it can also help ease the symptoms in of neuropathy in non-diabetics. If you have not done much exercise lately, do not overdo it. Start with some gentle exercises like brisk walking or swimming. Try to get at least 30 minutes of exercise each day.

Frequently Asked Questions

Can you have neuropathy and not have diabetes?

People who have diabetes also have a very high risk of neuropathy especially peripheral neuropathy. However, many people suffering from neuropathy do not have diabetes.

Diabetic peripheral neuropathy is caused by a long term elevation in blood sugar level that leads to nerve damage. Some people do not have symptoms but for others, the condition can be debilitating.

According to estimates, around 60 to 70% of diabetics will also have some type of neuropathy with peripheral neuropathy being the most common form.

Can you reverse neuropathy?

the focus of treament is management of the symptoms. While nerve damage may not be reversible, there are many ways to manage your symptoms including diet, supplements and lifestyle changes. For people with diabetic neuropathy, treatment includes keeping blood sugar under control.

What are natural remedies for neuropathy?

Neuropathy can be managed with a range of natural remedies including minerals, supplements, vitamins and oils. Lifestyle changes including a healthy diet and light exercise can also help. Some of the best natural remedies for neuropathy include :

cayenne pepper
B vitamins
certain essential oils
acupuncture
meditation
warm baths

Is walking good for neuropathy?

There is evidence that strngthening exercises can help manage the symptoms of peripheral neuropathy. Moderate exercise like walking is believed to be very good for your symptoms. Additionally, getting plenty of regular exercise can relieve inflammation and neuropathic pain as well as ehlping keep blood sugar levels under control.

What is the best vitamin for neuropathy?

The B vitamins are believed to be the most effective vitamin for managing the pain and inflammation caused by neuropathy. Thiamine or vitamin B-1 is thought to prevent damage to the cells as well as helping to fight inflammation and pain. It is also known that a deficiency in certain vitamins like B-12 is one of the major causes of peripheral neuropathy.

Final Thoughts

Peripheral neuropathy is a condition in which nerves are damaged. This can lead to pain, numbness and a tingling sensation in the hands and the feet.

There are a number of potential causes including diabetes, certain medications, vitasmin deficiency, infection, injury and chemotherapy treatment.

It is possible to control the symptoms with a range of vitamin, minerals and other supplements. these include the B vitamins, curcumin, magnesium, N-acetyl cysteine, Acetyl l-carnitine, rsveratrol and fish oil. Other potential treatments include tea tree and frankincense essential oils.

Lifestyle changes like a healthy diet and regular exercise regime can also have a positive effect on your symptoms.

Have you ever tried any of the vitamins and minerals mentioned in the article or do you take any supplements to help manage your condition?

Please let us know in the comments section. We would be very happy to hear from you.